The Paleo Diet: Can It Help Reduce the Risk of Coronary Artery Disease?

Joe Virzi
May 28, 2024By Joe Virzi

If you're looking for a dietary approach that may help reduce your risk of coronary artery disease, the Paleo diet is one option getting a lot of attention lately. But what exactly is the Paleo diet, and can it really make a difference for heart health? Let's take a closer look.

Paleo diet concept. Balanced food background on the table.  Copy space, dark background.

What is the Paleo Diet?

The Paleo diet aims to mimic the diet of our hunter-gatherer ancestors from the Paleolithic era, before the advent of agriculture and industrialized food production. This means focusing on foods that could be hunted or gathered naturally, such as:

- Meats (beef, poultry, fish, etc.)
- Eggs
- Fruits and vegetables
- Nuts and seeds
- Healthy fats (olive oil, avocado oil, etc.)

The Paleo diet eliminates grains, legumes, dairy, refined sugars, salt, and processed foods - items that were essentially non-existent before modern agriculture.

assorted fruits

Potential Benefits for Coronary Artery Disease


While more long-term research is still needed, some experts believe the Paleo diet may help reduce coronary artery disease risk through a few key mechanisms:

1. Improved blood lipid profiles - Early studies show the Paleo diet may lead to higher HDL ("good") cholesterol, lower triglycerides, and an improved total cholesterol to HDL ratio compared to other diets.


2. Reduced inflammation - By eliminating inflammatory foods like grains, legumes, and processed items, the Paleo diet may help lower systemic inflammation, which plays a role in atherosclerosis.


3. Weight loss - The Paleo diet eliminates many calorie-dense, nutrient-poor foods, which can lead to healthy weight loss - a key factor in coronary artery disease prevention.


4. Increased nutrient density - With its emphasis on vegetables, fruits, lean meats, and healthy fats, the Paleo diet provides a nutrient-dense dietary pattern high in antioxidants, fiber, and beneficial fatty acids.

native egg lot

A Balanced Perspective

While the principles of the Paleo diet show promise for heart health, it's an area that needs more rigorous study. The diet can also be quite restrictive and challenging to follow long-term for some people. As with any eating approach, it's wise to discuss the Paleo diet with your doctor, especially if you have existing medical conditions. Moderation and an emphasis on overall dietary quality are likely the keys for sustainable coronary artery disease prevention.

How Does the Paleo Diet Compare to Other Heart-Healthy Diets?

The Paleo diet scored poorly in the American Heart Association's ranking of diets for cardiovascular health benefits. It was placed in the bottom tier along with the ketogenic diet. 

A few reasons the Paleo diet ranked low: 

- Restricts fruits, vegetables, whole grains, and legumes, which are fiber-rich foods linked to reduced heart disease risk.

- Allows high intakes of saturated fat from animal sources like fatty meats and butter, which can raise LDL ("bad") cholesterol levels.

- Eliminates nutrient-dense foods like beans, lentils, and some fruits, potentially leading to nutrient deficiencies.

person cutting vegetables with knife

Top-Ranked Heart-Healthy Diets

The diets that scored best for heart health emphasize fruits, vegetables, whole grains, lean proteins, nuts, seeds, and healthy plant oils. These include:

- DASH diet (highest rank)

- Mediterranean diet

- Vegetarian diet

- Pescatarian (vegetarian + seafood) diet

These diets align with the AHA's guidelines of limiting saturated fat, sodium, and processed foods while providing plenty of fiber, antioxidants, and unsaturated healthy fats.

While the Paleo diet may lead to some short-term benefits like weight loss, nutrition experts caution that its restrictions on nutrient-dense plant foods make it less ideal for long-term heart health compared to diets like DASH, Mediterranean, and vegetarian patterns.